Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 17/20 | 0.77 |
| ▸ | CCND1 | P24385 | 15/20 | 0.77 |
| ▸ | CDK6 | Q00534 | 8/20 | 0.77 |
| ▸ | CCND2 | P30279 | 6/20 | 0.68 |
| ▸ | CCND3 | P30281 | 6/20 | 0.68 |
| ▸ | CDK2 | P24941 | 6/20 | 0.68 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.68 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.68 |
| ▸ | CDK1 | P06493 | 4/20 | 0.68 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.68 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.68 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.68 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.68 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | CASP1 | P29466 | 1/20 | 0.67 |
| ▸ | CASP7 | P55210 | 1/20 | 0.67 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5520815 | 0.90 | CDK4 (0.77) | CDK4CCND1CDK6CCND2CCND3 | |
| SCHEMBL30724198 | 0.87 | CDK4 (1.00) | CDK4CCND1CDK6CCND2CCND3 | |
| SCHEMBL5516177 | 0.86 | CDK4 (0.82) | CDK4CCND1CDK6CCND2CCND3 | |
| SCHEMBL6938615 | 0.83 | CDK4 (0.82) | CDK4CCND1CDK6CCND2CCND3 | |
| SCHEMBL6943064 | 0.83 | CDK4 (0.82) | CDK4CCND1CDK6CCND2CCND3 | |
| SCHEMBL30724193 | 0.83 | CDK4 (0.81) | CDK4CCND1CDK6CCND2CCND3 | |
| SCHEMBL5634391 | 0.82 | CDK2 (0.78) | CDK4CCND1CDK6CCND2CCND3 | |
| SCHEMBL5524764 | 0.82 | CDK2 (0.81) | CDK4CCND1CDK6CCND2CCND3 | |
| SCHEMBL5634313 | 0.82 | CYP1A2 (0.68) | CDK4CCND1CDK6CCND2CCND3 | |
| SCHEMBL10192614 | 0.81 | CDK4 (1.00) | CDK4CCND1CDK6CCND2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169778-B2 | Pteridinones as kinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2007-01-30 | — | — | US | claimed |
| EP-1409487-A1 | PTERIDINONES AS KINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-04-21 | — | — | EP | claimed |
| US-20030130286-A1 | Pteridinones as kinase inhibitors | DENNY WILLIAM ALEXANDER (NZ) | 2003-07-10 | — | — | US | claimed |
| WO-2001019825-A1 | PTERIDINONES AS KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-03-22 | — | — | WO | claimed |
| US-20070049600-A1 | PTERIDINONES AS KINASE INHIBITORS | WARNER-LAMBERT COMPANY | 2007-03-01 | — | — | US | disclosed |
| US-20070049600-A1 | PTERIDINONES AS KINASE INHIBITORS | WARNER-LAMBERT COMPANY | 2007-03-01 | — | — | US | disclosed |
| US-20070049600-A1 | PTERIDINONES AS KINASE INHIBITORS | WARNER-LAMBERT COMPANY | 2007-03-01 | — | — | US | disclosed |
| US-7169778-B2 | Pteridinones as kinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2007-01-30 | — | — | US | disclosed |
| US-7169778-B2 | Pteridinones as kinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2007-01-30 | — | — | US | disclosed |
| EP-1409487-A1 | PTERIDINONES AS KINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-04-21 | — | — | EP | disclosed |
| US-20030130286-A1 | Pteridinones as kinase inhibitors | DENNY WILLIAM ALEXANDER (NZ) | 2003-07-10 | — | — | US | disclosed |
| WO-2001019825-A1 | PTERIDINONES AS KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130286-A1 | Pteridinones as kinase inhibitors | CCNI, CCNK, CDK2 | CDK4 5/4885CCND1 32/4885CDK6 16/4885 |
| US-20070049600-A1 | PTERIDINONES AS KINASE INHIBITORS | CCNI, CCNK, CDK2 | CDK4 5/4885CCND1 21/4885CDK6 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.