Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 16/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5519341 | 1.00 | PTGDR2 (0.71) | PTGDR2MEN1KMT2ALMNAHTT | |
| SCHEMBL4130238 | 1.00 | PTGDR2 (0.71) | PTGDR2MEN1KMT2ALMNAHTT | |
| SCHEMBL4128110 | 0.90 | PTGDR2 (0.70) | PTGDR2MEN1KMT2ALMNAHTT | |
| SCHEMBL4128464 | 0.89 | PTGDR2 (0.75) | PTGDR2MEN1KMT2ALMNAHTT | |
| SCHEMBL4121220 | 0.89 | PTGDR2 (0.75) | PTGDR2MEN1KMT2ALMNAHTT | |
| SCHEMBL4116608 | 0.88 | PTGDR2 (0.76) | PTGDR2MEN1KMT2ALMNAHTT | |
| SCHEMBL4124409 | 0.88 | PTGDR2 (0.75) | PTGDR2MEN1KMT2ALMNAHTT | |
| SCHEMBL4115050 | 0.87 | PTGDR2 (0.72) | PTGDR2MEN1KMT2ALMNAHTT | |
| SCHEMBL13776298 | 0.86 | PTGDR2 (0.66) | PTGDR2MEN1KMT2ALMNAHTT | |
| SCHEMBL4129501 | 0.86 | PTGDR2 (0.73) | PTGDR2MEN1KMT2ALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740547-A1 | PGD2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005100321-A1 | PGD2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-10-27 | — | — | WO | disclosed |