Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Propionic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propionic Acid SCHEMBL11428745 | 0.94 | FFAR3 (0.67) | FFAR3TDP1ALDH1A1TP53CYP1A2 | |
| Propionic Acid SCHEMBL1237963 | 0.94 | FFAR3 (0.67) | FFAR3TDP1ALDH1A1TP53CYP1A2 | |
| Propionic Acid SCHEMBL29184103 | 0.91 | FFAR3 (0.62) | FFAR3TDP1ALDH1A1TP53CYP1A2 | |
| Butyric Acid SCHEMBL27473502 | 0.88 | FFAR3 (0.59) | FFAR3TDP1ALDH1A1CYP1A2HDAC1 | |
| Butyric Acid SCHEMBL19800894 | 0.86 | FFAR3 (0.56) | FFAR3TDP1ALDH1A1CYP1A2HDAC1 | |
| Lactic Acid SCHEMBL11064545 | 0.86 | TP53 (0.61) | FFAR3TDP1ALDH1A1LCKFYN | |
| Acetic Acid SCHEMBL10637065 | 0.84 | FFAR3 (0.58) | FFAR3TDP1ALDH1A1LCKFYN | |
| Propionic Acid SCHEMBL386699 | 0.84 | FFAR3 (0.83) | FFAR3TDP1ALDH1A1LCKFYN | |
| Acetic Acid SCHEMBL21806304 | 0.84 | FFAR3 (0.58) | FFAR3TDP1ALDH1A1LCKFYN | |
| Propionic Acid SCHEMBL2461940 | 0.84 | FFAR3 (0.83) | FFAR3TDP1ALDH1A1LCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101262845-A | Personal care products incorporating cellulosic fatty acid esters | EASTMAN CHEM CO (US) | 2008-09-10 | — | — | CN | disclosed |
| US-20070053855-A1 | Personal care products incorporating cellulosic fatty acid esters | EASTMAN CHEMICAL COMPANY | 2007-03-08 | — | — | US | disclosed |