Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 14/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TACR2 | P21452 | 1/20 | 0.43 |
| ▸ | TACR3 | P29371 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5528169 | 1.00 | TACR1 (0.56) | TACR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL5522711 | 1.00 | TACR1 (0.56) | TACR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL5527476 | 0.91 | TACR1 (0.58) | TACR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL5522702 | 0.91 | TACR1 (0.58) | TACR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL3182264 | 0.89 | TACR1 (0.58) | TACR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL3184443 | 0.89 | TACR1 (0.58) | TACR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL3166876 | 0.89 | TACR1 (0.58) | TACR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL5520589 | 0.83 | TACR1 (0.81) | TACR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL5526882 | 0.83 | TACR1 (0.81) | TACR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL13378026 | 0.81 | TACR1 (0.65) | TACR1CYP3A4CYP2C8CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070161695-A1 | Hydroisoindoline tachykinin receptor antagonists | VYNE THERAPEUTICS INC. (F/K/A MENLO THERAPEUTICS INC. AND SUCCESSOR-IN-INTEREST TO VYNE PHARMACEUTICALS LTD., F/K/A FOAMIX PHARMACEUTICALS LTD.) | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161695-A1 | Hydroisoindoline tachykinin receptor antagonists | TACR1, TACR2, NPSR1 | TACR1 1/4885CYP3A4 3228/4885CYP2C8 3154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.