Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 7/20 | 0.72 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.72 |
| ▸ | FLT1 | P17948 | 11/20 | 0.63 |
| ▸ | EGFR | P00533 | 10/20 | 0.63 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.51 |
| ▸ | IKBKB | O14920 | 2/20 | 0.51 |
| ▸ | CHUK | O15111 | 2/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | INSR | P06213 | 2/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | FLT3 | P36888 | 2/20 | 0.51 |
| ▸ | SGK1 | O00141 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5532194 | 0.93 | PRKCQ (0.73) | PRKCQPRKCDFLT1EGFRMAP3K11 | |
| SCHEMBL5514315 | 0.86 | PRKCQ (0.64) | PRKCQPRKCDFLT1EGFRFLT3 | |
| SCHEMBL5512977 | 0.85 | PRKCQ (0.55) | PRKCQPRKCDFLT1EGFRMAP3K11 | |
| SCHEMBL5524335 | 0.84 | EGFR (0.66) | PRKCQPRKCDFLT1EGFRFLT3 | |
| SCHEMBL5530012 | 0.83 | PRKCQ (0.69) | PRKCQPRKCDFLT1EGFRLCK | |
| SCHEMBL5517780 | 0.82 | EGFR (0.62) | PRKCQPRKCDFLT1EGFRCDK1 | |
| SCHEMBL7126230 | 0.79 | EGFR (0.79) | PRKCQPRKCDFLT1EGFR | |
| SCHEMBL5531714 | 0.79 | PRKCQ (0.49) | PRKCQPRKCDFLT1EGFRSYK | |
| SCHEMBL7116962 | 0.79 | FLT1 (0.74) | PRKCQPRKCDFLT1EGFR | |
| SCHEMBL5518096 | 0.78 | PRKCQ (0.71) | PRKCQPRKCDFLT1EGFRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070082880-A1 | Thieno [2,3-B] pyridine-5-carbonitriles as protein kinase inhibitors | WYETH | 2007-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070082880-A1 | Thieno [2,3-B] pyridine-5-carbonitriles as protein kinase inhibitors | MAP4K2, CNKSR1, MAP3K1 | PRKCQ 286/4885PRKCD 356/4885FLT1 1662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.