Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | HPGD | P15428 | 6/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1385352 | 0.88 | KCNA5 (0.53) | KCNA5KCNH2ALDH1A1MAPTNPSR1 | |
| SCHEMBL1382239 | 0.86 | KCNA5 (0.53) | KCNA5KCNH2ALDH1A1MAPTNPSR1 | |
| SCHEMBL3124134 | 0.78 | KCNA5 (0.54) | KCNA5KCNH2ALDH1A1MAPTMEN1 | |
| SCHEMBL1383656 | 0.78 | KDM4E (0.53) | KCNA5KCNH2ALDH1A1MAPTNPSR1 | |
| SCHEMBL3115867 | 0.77 | KCNA5 (0.48) | KCNA5KCNH2ALDH1A1MAPTNPSR1 | |
| SCHEMBL3110766 | 0.76 | KCNA5 (0.54) | KCNA5KCNH2ALDH1A1MAPTNPSR1 | |
| SCHEMBL1385829 | 0.75 | KCNA5 (0.53) | KCNA5KCNH2ALDH1A1MAPTMEN1 | |
| SCHEMBL1381879 | 0.75 | KCNA5 (0.53) | KCNA5KCNH2ALDH1A1MAPTMEN1 | |
| SCHEMBL1381875 | 0.75 | KCNA5 (0.53) | KCNA5KCNH2ALDH1A1MAPTMEN1 | |
| SCHEMBL1384650 | 0.75 | KCNA5 (0.53) | KCNA5KCNH2ALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667979-A4 | ISOQUINOLINE POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2007-04-18 | — | — | EP | disclosed |
| EP-1667979-A2 | ISOQUINOLINE POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005030130-A2 | ISOQUINOLINE POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2005-04-07 | — | — | WO | disclosed |