Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.86 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.86 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5528242 | 1.00 | MEN1 (0.86) | MEN1KMT2APTGDR2MAPTALDH1A1 | |
| SCHEMBL2086953 | 0.93 | MEN1 (1.00) | MEN1KMT2APTGDR2MAPTALDH1A1 | |
| SCHEMBL2086952 | 0.93 | MEN1 (1.00) | MEN1KMT2APTGDR2MAPTALDH1A1 | |
| SCHEMBL2086720 | 0.91 | KMT2A (0.72) | MEN1KMT2APTGDR2MAPTALDH1A1 | |
| SCHEMBL2087668 | 0.90 | KMT2A (0.86) | MEN1KMT2APTGDR2MAPTALDH1A1 | |
| SCHEMBL2089256 | 0.89 | KMT2A (0.83) | MEN1KMT2APTGDR2MAPTALDH1A1 | |
| SCHEMBL2088126 | 0.88 | MEN1 (0.67) | MEN1KMT2APTGDR2MAPTALDH1A1 | |
| SCHEMBL2088135 | 0.88 | MEN1 (0.82) | MEN1KMT2APTGDR2MAPTALDH1A1 | |
| SCHEMBL2088137 | 0.88 | MEN1 (0.82) | MEN1KMT2APTGDR2MAPTALDH1A1 | |
| SCHEMBL2087143 | 0.87 | MEN1 (0.86) | MEN1KMT2APTGDR2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740171-A1 | INDOL-1-YL-ACETIC ACID DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005094816-A1 | INDOL-1-YL-ACETIC ACID DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2005-10-13 | — | — | WO | disclosed |