Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 16/20 | 0.60 |
| ▸ | EGFR | P00533 | 12/20 | 0.60 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.60 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | FECH | P22830 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.49 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1105274 | 0.88 | ERBB2 (0.56) | ERBB2EGFRERBB3ERBB4KCNH2 | |
| SCHEMBL5002315 | 0.88 | ERBB2 (0.56) | ERBB2EGFRERBB3ERBB4KCNH2 | |
| SCHEMBL5534433 | 0.88 | EGFR (0.50) | ERBB2EGFRERBB3ERBB4KCNH2 | |
| SCHEMBL2747899 | 0.80 | ERBB2 (0.63) | ERBB2EGFRERBB3ERBB4KCNH2 | |
| SCHEMBL2748335 | 0.80 | ERBB2 (0.63) | ERBB2EGFRERBB3ERBB4KCNH2 | |
| Iodide SCHEMBL3900898 | 0.79 | ERBB2 (0.62) | ERBB2EGFRERBB3ERBB4KCNH2 | |
| SCHEMBL4866251 | 0.78 | EGFR (0.67) | ERBB2EGFRERBB3ERBB4KCNH2 | |
| SCHEMBL3510089 | 0.77 | ERBB2 (0.51) | ERBB2EGFRERBB3ERBB4KCNH2 | |
| SCHEMBL1096558 | 0.77 | ERBB2 (0.59) | ERBB2EGFRERBB3ERBB4KCNH2 | |
| SCHEMBL5005180 | 0.77 | EGFR (0.56) | ERBB2EGFRERBB3ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070270425-A1 | SUBSTITUTED PYRIMIDINYL OXIME KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-22 | — | — | US | claimed |
| US-8367825-B2 | Substituted pyrimidinyl oxime kinase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-02-05 | — | — | US | disclosed |
| US-20120157412-A1 | Substituted Pyrimidinyl Oxime Kinase Inhibitors | BATTISTA KATHLEEN A (US) | 2012-06-21 | — | — | US | disclosed |
| US-20070270425-A1 | SUBSTITUTED PYRIMIDINYL OXIME KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157412-A1 | Substituted Pyrimidinyl Oxime Kinase Inhibitors | MAP3K2, MAP3K1, MAP3K20 | ERBB2 124/4885EGFR 1201/4885ERBB3 348/4885 |
| US-20070270425-A1 | SUBSTITUTED PYRIMIDINYL OXIME KINASE INHIBITORS | MAP3K2, MAP3K1, MAP3K20 | ERBB2 124/4885EGFR 1201/4885ERBB3 348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.