Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 8/20 | 0.42 |
| ▸ | EDNRB | P24530 | 3/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4774360 | 0.92 | EDNRA (0.42) | EDNRAEDNRBAGTR1 | |
| SCHEMBL4770986 | 0.89 | EDNRA (0.41) | EDNRAEDNRBAGTR1 | |
| SCHEMBL4767662 | 0.89 | EDNRA (0.43) | EDNRAEDNRBAGTR1 | |
| SCHEMBL4773398 | 0.87 | EDNRA (0.41) | EDNRAEDNRBAGTR1 | |
| SCHEMBL4764479 | 0.86 | EDNRA (0.43) | EDNRAEDNRBAGTR1 | |
| SCHEMBL4764952 | 0.86 | EDNRA (0.42) | EDNRAEDNRB | |
| SCHEMBL4769169 | 0.85 | EDNRA (0.43) | EDNRAEDNRBAGTR1 | |
| SCHEMBL5532213 | 0.85 | EDNRA (0.42) | EDNRAEDNRBAGTR1 | |
| SCHEMBL5789923 | 0.85 | EDNRA (0.42) | EDNRAEDNRBAGTR1 | |
| SCHEMBL4769634 | 0.84 | EDNRA (0.41) | EDNRAEDNRBAGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1741713-A2 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | Bristol-Myers Squibb Company (US) | 2007-01-10 | — | — | EP | claimed |
| EP-1237888-A2 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2002-09-11 | — | — | EP | claimed |
| WO-2001044239-A2 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB CO. (US) | 2001-06-21 | — | — | WO | claimed |
| EP-1237888-B1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2006-09-13 | — | — | EP | disclosed |