Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.32 |
| ▸ | FEN1 | P39748 | 2/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4774269 | 0.92 | EDNRA (0.34) | TP53MAPTALOX5APFEN1EDNRA | |
| SCHEMBL4774809 | 0.91 | MAPT (0.34) | TP53MAPTEDNRA | |
| SCHEMBL4774065 | 0.89 | ALOX5AP (0.32) | TP53MAPTALOX5APFEN1EDNRA | |
| SCHEMBL4772931 | 0.89 | ALOX5AP (0.32) | TP53MAPTALOX5APFEN1EDNRA | |
| SCHEMBL5523997 | 0.89 | EDNRA (0.36) | TP53MAPTEDNRA | |
| SCHEMBL4769236 | 0.89 | EDNRA (0.38) | TP53MAPTEDNRA | |
| SCHEMBL4764635 | 0.88 | EDNRA (0.33) | EDNRA | |
| SCHEMBL5529118 | 0.87 | EDNRA (0.38) | ALOX5APFEN1EDNRA | |
| SCHEMBL4764701 | 0.87 | EDNRB (0.34) | ALOX5APFEN1EDNRA | |
| SCHEMBL4770625 | 0.84 | ALOX5AP (0.35) | TP53MAPTALOX5APFEN1EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1741713-A2 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | Bristol-Myers Squibb Company (US) | 2007-01-10 | — | — | EP | disclosed |
| EP-1237888-B1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2006-09-13 | — | — | EP | disclosed |
| US-6852745-B2 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-02-08 | — | — | US | disclosed |
| US-6835741-B2 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | BRISTOL-MYERS SQUIBB COMPANY | 2004-12-28 | — | — | US | disclosed |
| US-6638937-B2 | As antihypertensive agents; for therapy of disorders related to renal, glomerular and mesangial cell function; therapy of endotoxemia or endotoxin shock as well as hemorrhagic shock; useful in alleviation of pain associated cancer | BRISTOL-MYERS SQUIBB CO. | 2003-10-28 | — | — | US | disclosed |