Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL2994826 | 0.94 | EGFR (0.42) | EGFRIGF1RCCNT1CDK9CHUK | |
| SCHEMBL2994829 | 0.87 | IGF1R (0.37) | EGFRIGF1RCCNT1CDK9CHUK | |
| SCHEMBL5531129 | 0.86 | IGF1R (0.42) | EGFRIGF1RCD274 | |
| SCHEMBL2985996 | 0.84 | IGF1R (0.48) | EGFRIGF1RCCNT1CDK9CHUK | |
| SCHEMBL2994815 | 0.82 | IGF1R (0.47) | EGFRIGF1RCCNT1CDK9CHUK | |
| Trifluoroacetic Acid SCHEMBL2991605 | 0.81 | IGF1R (0.38) | EGFRIGF1RCD274CCNT1CDK9 | |
| SCHEMBL2982560 | 0.81 | IGF1R (0.48) | EGFRIGF1RCCNT1CDK9CHUK | |
| SCHEMBL2996917 | 0.81 | IGF1R (0.45) | IGF1RCCNT1CDK9CHUKINSR | |
| SCHEMBL5531332 | 0.80 | IGF1R (0.42) | IGF1RCCNT1CDK9CHUKINSR | |
| SCHEMBL2991608 | 0.80 | IGF1R (0.37) | EGFRIGF1RCCNT1CDK9CHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799691-A1 | NOVEL BIS-AZAINDOLE DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006037875-A1 | NOVEL BIS-AZAINDOLE DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2006-04-13 | — | — | WO | disclosed |