Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 18/20 | 0.57 |
| ▸ | AKT2 | P31751 | 18/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2896561 | 0.85 | AKT1 (0.78) | AKT1AKT2EGFRPDGFRBFGFR1 | |
| SCHEMBL13233222 | 0.78 | AKT1 (0.55) | AKT1AKT2EGFRPDGFRBFGFR1 | |
| SCHEMBL3859087 | 0.75 | AKT1 (0.43) | AKT1AKT2 | |
| SCHEMBL13263614 | 0.75 | AKT1 (0.50) | AKT1AKT2EGFRPDGFRBFGFR1 | |
| SCHEMBL2897996 | 0.74 | AKT1 (0.65) | AKT1AKT2EGFRPDGFRBFGFR1 | |
| SCHEMBL2890654 | 0.73 | AKT1 (0.48) | AKT1AKT2EGFRPDGFRBFGFR1 | |
| SCHEMBL2894176 | 0.73 | AKT1 (1.00) | AKT1AKT2 | |
| SCHEMBL13263639 | 0.66 | AKT1 (0.77) | AKT1AKT2 | |
| SCHEMBL1350832 | 0.65 | ADORA1 (0.53) | AKT1AKT2EGFRPDGFRBFGFR1 | |
| Trifluoroacetic Acid SCHEMBL1351970 | 0.64 | FGFR1 (0.53) | AKT1AKT2EGFRPDGFRBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737861-A1 | INHIBITORS OF AKT ACTIVITY | Merck & Co., Inc. (US) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005100356-A1 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2005-10-27 | — | — | WO | disclosed |