Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 19/20 | 0.65 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2003173 | 0.88 | GRM2 (0.84) | GRM2 | |
| SCHEMBL12611998 | 0.84 | GRM2 (0.66) | GRM2CYSLTR1 | |
| SCHEMBL1996029 | 0.79 | GRM2 (1.00) | GRM2 | |
| SCHEMBL12611059 | 0.75 | GRM2 (0.78) | GRM2CYSLTR1MRGPRX4 | |
| SCHEMBL1997138 | 0.68 | GRM2 (0.65) | GRM2MRGPRX4 | |
| SCHEMBL1997175 | 0.68 | GRM2 (1.00) | GRM2 | |
| SCHEMBL2001373 | 0.67 | GRM2 (0.71) | GRM2MRGPRX4 | |
| SCHEMBL1998223 | 0.67 | GRM2 (0.70) | GRM2MRGPRX4 | |
| SCHEMBL1997540 | 0.66 | GRM2 (0.66) | GRM2 | |
| SCHEMBL1997237 | 0.66 | GRM2 (0.71) | GRM2MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1855670-A2 | BENZAZOLE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merck & Co., Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006091496-A2 | BENZAZOLE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK & CO., INC. (US) | 2006-08-31 | — | — | WO | disclosed |