Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 7/20 | 0.41 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5521109 | 0.93 | ACACB (0.41) | ACACBHMOX1ROCK2ROCK1HPGD | |
| SCHEMBL5522141 | 0.90 | ACACB (0.41) | ACACBHMOX1HPGDSMN1; SMN2SCN9A | |
| SCHEMBL5520765 | 0.88 | HSD17B10 (0.44) | ACACBHPGDSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL5519107 | 0.88 | ACACB (0.46) | ACACBROCK2ROCK1HPGDSMN1; SMN2 | |
| SCHEMBL5516274 | 0.84 | SMN1; SMN2 (0.49) | ACACBHPGDSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL5519303 | 0.84 | SMN1; SMN2 (0.49) | ACACBHPGDSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL5518049 | 0.84 | ACACB (0.42) | ACACBHPGDSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL5515594 | 0.83 | PARP10 (0.38) | HPGDSMN1; SMN2ALDH1A1SCN9A | |
| SCHEMBL5525322 | 0.83 | ACACB (0.51) | ACACBHPGDSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL14451329 | 0.81 | HSD17B10 (0.43) | ACACBHPGDSMN1; SMN2L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070167452-A1 | Therapeutic amide derivatives | PFIZER, INC. | 2007-07-19 | — | — | US | disclosed |
| US-20070167452-A1 | Therapeutic amide derivatives | PFIZER, INC. | 2007-07-19 | — | — | US | disclosed |
| US-20070167452-A1 | Therapeutic amide derivatives | PFIZER, INC. | 2007-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167452-A1 | Therapeutic amide derivatives | GRIN1, GRIN2B, GRIN3A | ACACB 1086/4885HMOX1 4717/4885ROCK2 4012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.