Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 14/20 | 0.60 |
| ▸ | CDK1 | P06493 | 13/20 | 0.60 |
| ▸ | CCNT1 | O60563 | 12/20 | 0.60 |
| ▸ | CCNB1 | P14635 | 12/20 | 0.60 |
| ▸ | CDK9 | P50750 | 12/20 | 0.60 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.60 |
| ▸ | CCNE2 | O96020 | 5/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.60 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.60 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.60 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.55 |
| ▸ | CDK7 | P50613 | 8/20 | 0.55 |
| ▸ | CCNH | P51946 | 8/20 | 0.55 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.55 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.50 |
| ▸ | CDK4 | P11802 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 2/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.45 |
| ▸ | CCND3 | P30281 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1474139 | 0.88 | JAK3 (0.57) | CDK2CDK1CCNT1CCNB1CDK9 | |
| Ammonia Solution, Strong SCHEMBL1890400 | 0.84 | CDK2 (0.46) | CDK2CDK1CCNT1CCNB1CDK9 | |
| Ammonia Solution, Strong SCHEMBL1880722 | 0.84 | PTK2 (0.49) | CDK2CDK1CCNT1CCNB1CDK9 | |
| SCHEMBL1474777 | 0.84 | AURKA (0.56) | CDK2CDK1CCNT1CCNB1CDK9 | |
| SCHEMBL1476189 | 0.84 | JAK3 (0.57) | CDK2CDK1CCNT1CCNB1CDK9 | |
| SCHEMBL1475250 | 0.80 | JAK3 (0.56) | CDK2CDK1CCNT1CCNB1CDK9 | |
| SCHEMBL4972364 | 0.78 | JAK3 (0.55) | CDK2CDK1CCNT1CCNB1CDK9 | |
| SCHEMBL4973658 | 0.77 | JAK3 (0.56) | CDK2CDK1CCNT1CCNB1CDK9 | |
| SCHEMBL1474887 | 0.75 | SYK (0.56) | CDK2CDK1CDK5SYKNTRK1 | |
| SCHEMBL1606970 | 0.74 | SYK (0.60) | CDK2CDK1CCNT1CCNB1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070203161-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203161-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | JAK3, JAK2, JAK1 | CDK2 236/4885CDK1 155/4885CCNT1 1524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.