Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.46 |
| ▸ | TP53 | P04637 | 5/20 | 0.46 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | HTT | P42858 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3054066 | 0.88 | MAPT (0.43) | MAPTSMN1; SMN2TP53CCR2CCR5 | |
| SCHEMBL3052132 | 0.82 | MAPT (0.48) | MAPTSMN1; SMN2TP53CCR2CCR5 | |
| SCHEMBL3052187 | 0.81 | HTT (0.57) | MAPTSMN1; SMN2TP53CCR2CCR5 | |
| SCHEMBL3051396 | 0.78 | TP53 (0.55) | MAPTSMN1; SMN2TP53CCR2CCR5 | |
| SCHEMBL5539670 | 0.77 | MAPT (0.45) | MAPTSMN1; SMN2TP53CCR2CCR5 | |
| SCHEMBL10276991 | 0.77 | MAPT (0.45) | MAPTSMN1; SMN2TP53CCR2CCR5 | |
| SCHEMBL3051775 | 0.76 | MAPT (0.46) | MAPTSMN1; SMN2TP53CCR2CCR5 | |
| SCHEMBL3055646 | 0.76 | TP53 (0.58) | MAPTSMN1; SMN2TP53CCR2CCR5 | |
| SCHEMBL3060981 | 0.75 | MAPT (0.44) | MAPTSMN1; SMN2TP53CCR2CCR5 | |
| SCHEMBL3052199 | 0.75 | MAPT (0.46) | MAPTSMN1; SMN2TP53CCR2CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799689-A1 | FURAZANO `3, 4-B ! PYRAZYNES AND THEIR USE AS ANTI-TUMOR AGENTS | Compass Pharmaceuticals LLC (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006044402-A1 | FURAZANO `3, 4-B ! PYRAZYNES AND THEIR USE AS ANTI-TUMOR AGENTS | COMPASS PHARMACEUTICALS LLC (US) | 2006-04-27 | — | — | WO | disclosed |