Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3054070 | 0.87 | MAPT (0.39) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL3052199 | 0.78 | MAPT (0.46) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL3051396 | 0.77 | TP53 (0.55) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL3048542 | 0.77 | MAPT (0.47) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL5539670 | 0.76 | MAPT (0.45) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL3051775 | 0.76 | MAPT (0.46) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL10276991 | 0.74 | MAPT (0.45) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL4269856 | 0.74 | MAPT (0.45) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL3059036 | 0.73 | TP53 (0.53) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL3045625 | 0.73 | MEN1 (0.45) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799689-A1 | FURAZANO `3, 4-B ! PYRAZYNES AND THEIR USE AS ANTI-TUMOR AGENTS | Compass Pharmaceuticals LLC (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006044402-A1 | FURAZANO `3, 4-B ! PYRAZYNES AND THEIR USE AS ANTI-TUMOR AGENTS | COMPASS PHARMACEUTICALS LLC (US) | 2006-04-27 | — | — | WO | disclosed |