Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.73 |
| ▸ | USP2 | O75604 | 1/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 6/20 | 0.69 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | SLC16A1 | P53985 | 4/20 | 0.66 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.66 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5533347 | 1.00 | MEN1 (0.73) | MEN1KMT2AUSP2POLBMAPT | |
| SCHEMBL2086833 | 0.93 | MEN1 (0.84) | MEN1KMT2AUSP2POLBMAPT | |
| SCHEMBL2086836 | 0.93 | MEN1 (0.84) | MEN1KMT2AUSP2POLBMAPT | |
| SCHEMBL2087522 | 0.90 | MEN1 (0.81) | MEN1KMT2AUSP2POLBMAPT | |
| SCHEMBL2087524 | 0.90 | MEN1 (0.81) | MEN1KMT2AUSP2POLBMAPT | |
| SCHEMBL2089222 | 0.87 | MEN1 (0.83) | MEN1KMT2AUSP2POLBMAPT | |
| SCHEMBL2089221 | 0.87 | MEN1 (0.83) | MEN1KMT2AUSP2POLBMAPT | |
| SCHEMBL2087919 | 0.86 | MEN1 (0.77) | MEN1KMT2AUSP2POLBMAPT | |
| SCHEMBL2087921 | 0.86 | MEN1 (0.77) | MEN1KMT2AUSP2POLBMAPT | |
| SCHEMBL2087549 | 0.85 | MEN1 (0.82) | MEN1KMT2AUSP2POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740171-A1 | INDOL-1-YL-ACETIC ACID DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005094816-A1 | INDOL-1-YL-ACETIC ACID DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2005-10-13 | — | — | WO | disclosed |