Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 19/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002628 | 0.84 | PPARG (0.48) | GRM2PPARGPPARDPPARA | |
| SCHEMBL1996376 | 0.82 | GRM2 (0.75) | GRM2PPARGPPARDPPARA | |
| SCHEMBL1995376 | 0.77 | GRM2 (0.73) | GRM2 | |
| SCHEMBL2000285 | 0.77 | GRM2 (0.49) | GRM2 | |
| SCHEMBL1999842 | 0.77 | GRM2 (0.73) | GRM2 | |
| SCHEMBL2002625 | 0.77 | GRM2 (0.73) | GRM2 | |
| SCHEMBL1996622 | 0.76 | GRM2 (0.73) | GRM2 | |
| SCHEMBL1998620 | 0.76 | GRM2 (0.63) | GRM2PPARGPPARDPPARA | |
| SCHEMBL1997997 | 0.75 | GRM2 (0.73) | GRM2 | |
| SCHEMBL1997582 | 0.75 | GRM2 (0.73) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1855670-A2 | BENZAZOLE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merck & Co., Inc. (US) | 2007-11-21 | — | — | EP | claimed |
| WO-2006091496-A2 | BENZAZOLE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK & CO., INC. (US) | 2006-08-31 | — | — | WO | claimed |
| EP-1855670-A2 | BENZAZOLE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merck & Co., Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006091496-A2 | BENZAZOLE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK & CO., INC. (US) | 2006-08-31 | — | — | WO | disclosed |