Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.93 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.93 |
| ▸ | MEN1 | O00255 | 5/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.80 |
| ▸ | LMNA | P02545 | 3/20 | 0.80 |
| ▸ | APEX1 | P27695 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL30084682 | 1.00 | CYP3A4 (0.93) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL30084681 | 1.00 | CYP3A4 (0.93) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL30473273 | 1.00 | CYP3A4 (0.93) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL20527931 | 1.00 | — | — | |
| Choline SCHEMBL28702639 | 0.97 | CYP3A4 (0.87) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL5533613 | 0.97 | CYP3A4 (0.87) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL18918663 | 0.97 | CYP3A4 (0.87) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL18918665 | 0.97 | CYP3A4 (0.87) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL18918664 | 0.97 | CYP3A4 (0.87) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL23036016 | 0.96 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196221-B2 | Reaction product of quaternary ammonium salt and metal compound; electrolyte, catalyst | SCIONIX LIMITED (GB) | 2007-03-27 | — | — | US | disclosed |
| EP-1322591-B1 | IONIC LIQUIDS AND THEIR USE | SCIONIX LTD (GB) | 2005-03-02 | — | — | EP | disclosed |
| US-20040054231-A1 | Reaction product of quaternary ammonium salt and metal compound; electrolyte, catalyst | SCIONIX LIMITED (GB) | 2004-03-18 | — | — | US | disclosed |
| EP-1322591-A2 | IONIC LIQUIDS AND THEIR USE | Scionix Limited (GB) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002026381-A2 | IONIC LIQUIDS AND THEIR USE | SCIONIX LIMITED (GB) | 2002-04-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040054231-A1 | Reaction product of quaternary ammonium salt and metal compound; electrolyte, catalyst | KCNN4, SCO2, CLIC4 | CYP3A4 2103/4885SLC5A7 3733/4885MEN1 3726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.