Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.75 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | XBP1 | P17861 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | SLC16A1 | P53985 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2087858 | 0.96 | MEN1 (0.76) | MEN1KMT2AALDH1A1PTGDR2KDM4E | |
| SCHEMBL2087855 | 0.96 | MEN1 (0.76) | MEN1KMT2AALDH1A1PTGDR2KDM4E | |
| SCHEMBL2088606 | 0.91 | MEN1 (0.86) | MEN1KMT2AALDH1A1PTGDR2KDM4E | |
| SCHEMBL2088609 | 0.91 | MEN1 (0.86) | MEN1KMT2AALDH1A1PTGDR2KDM4E | |
| SCHEMBL2089173 | 0.89 | MEN1 (0.76) | MEN1KMT2AALDH1A1PTGDR2KDM4E | |
| SCHEMBL2089170 | 0.89 | MEN1 (0.76) | MEN1KMT2AALDH1A1PTGDR2KDM4E | |
| SCHEMBL2087942 | 0.86 | MEN1 (1.00) | MEN1KMT2AALDH1A1PTGDR2KDM4E | |
| SCHEMBL2087939 | 0.86 | MEN1 (1.00) | MEN1KMT2AALDH1A1PTGDR2KDM4E | |
| SCHEMBL2087601 | 0.85 | MEN1 (0.76) | MEN1KMT2AALDH1A1PTGDR2KDM4E | |
| SCHEMBL2087602 | 0.85 | MEN1 (0.76) | MEN1KMT2AALDH1A1PTGDR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740171-A1 | INDOL-1-YL-ACETIC ACID DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2007-01-10 | — | — | EP | claimed |
| WO-2005094816-A1 | INDOL-1-YL-ACETIC ACID DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2005-10-13 | — | — | WO | claimed |