Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Timolol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.98 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.98 |
| ▸ | HTR1A | P08908 | 1/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.98 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.98 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.98 |
| ▸ | DRD1 | P21728 | 1/20 | 0.98 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.98 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.98 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.83 |
| ▸ | BLM | P54132 | 1/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Timolol SCHEMBL7591293 | 1.00 | CYP1A2 (0.98) | CYP1A2ADRB2ADRB1CYP3A4HTR1A | |
| Timolol SCHEMBL222970 | 0.99 | CYP1A2 (1.00) | CYP1A2ADRB2ADRB1CYP3A4HTR1A | |
| Timolol SCHEMBL1587691 | 0.99 | CYP1A2 (1.00) | CYP1A2ADRB2ADRB1CYP3A4HTR1A | |
| Timolol SCHEMBL2553603 | 0.99 | CYP1A2 (1.00) | CYP1A2ADRB2ADRB1CYP3A4HTR1A | |
| Timolol SCHEMBL4912 | 0.99 | CYP1A2 (1.00) | CYP1A2ADRB2ADRB1CYP3A4HTR1A | |
| Timolol SCHEMBL8858736 | 0.98 | CYP1A2 (0.98) | CYP1A2ADRB2ADRB1CYP3A4HTR1A | |
| Timolol SCHEMBL2356059 | 0.98 | CYP1A2 (0.98) | CYP1A2ADRB2ADRB1CYP3A4HTR1A | |
| Timolol SCHEMBL16094075 | 0.98 | CYP1A2 (0.98) | CYP1A2ADRB2ADRB1CYP3A4HTR1A | |
| Timolol SCHEMBL11418545 | 0.98 | CYP1A2 (0.98) | CYP1A2ADRB2ADRB1CYP3A4HTR1A | |
| Timolol SCHEMBL8858730 | 0.98 | CYP1A2 (0.98) | CYP1A2ADRB2ADRB1CYP3A4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119064515-A | Separation and determination method of eye drop related impurities of timolol bemeflone | 杭州民生药业股份有限公司 | 2024-12-03 | — | — | CN | claimed |
| EP-2485691-B1 | OPHTHALMIC DRUG DELIVERY | EYENOVIA INC (US) | 2020-03-18 | — | — | EP | claimed |
| EP-0305496-A4 | TIMOLOL DERIVATIVES. | INSITE VISION INC (US) | 1989-07-11 | — | — | EP | claimed |
| EP-0305496-A1 | TIMOLOL DERIVATIVES | INSITE VISION, INC. (US) | 1989-03-08 | — | — | EP | claimed |
| WO-1988007044-A1 | TIMOLOL DERIVATIVES | INSITE VISION, INC. (US) | 1988-09-22 | — | — | WO | claimed |
| CN-116327482-A | Apparatus and method for ocular injection | 科尼尔赛德生物医学公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-110302004-B | Apparatus and method for ocular injection | 科尼尔赛德生物医学公司 | 2023-04-28 | — | — | CN | disclosed |
| CN-110545850-A | Releasable conjugates | QUIAPEG PHARMACEUTICALS AB | 2019-12-06 | — | — | CN | disclosed |
| US-RE39588-E1 | Transdermal drug delivery device | ALZA CORPORATION (US) | 2007-04-24 | — | — | US | disclosed |
| CN-1906182-A | Nitrooxyderivatives of antihypertensive agents | NICOX SA (FR) | 2007-01-31 | — | — | CN | disclosed |
| US-7053068-B2 | Chitosan-thio-amidine conjugates and their cosmetic as well as pharmaceutic use | MUCOBIOMER BIOTECHNOLOGISCHE FORSCHUNGS- UND ENTWICKLUNGS GESMBH (AT) | 2006-05-30 | — | — | US | disclosed |
| US-20040236095-A1 | Chitosan-thio-amidine conjugates and their cosmetic as well as pharmeceutic use | MUCOBIOMER BIOTECHNOLOGISCHE FORSCHUNGS-UND ENTWICKLUNGS GESMBH (AT) | 2004-11-25 | — | — | US | disclosed |
| EP-0305496-A4 | TIMOLOL DERIVATIVES. | INSITE VISION INC (US) | 1989-07-11 | — | — | EP | disclosed |
| US-4837027-A | THERAPEUTIC AGENT STORED AS SALT, MOISTURE ACTIVATES | ALZA CORPORATION (US) | 1989-06-06 | — | — | US | disclosed |
| EP-0316065-A2 | Improved transdermal drug delivery device | ALZA CORPORATION (US) | 1989-05-17 | — | — | EP | disclosed |
| EP-0305496-A1 | TIMOLOL DERIVATIVES | INSITE VISION, INC. (US) | 1989-03-08 | — | — | EP | disclosed |
| US-4781924-A | RELEASE BY MOISTURE ACTIVATOR | ALZA CORPORATION (US) | 1988-11-01 | — | — | US | disclosed |
| WO-1988007044-A1 | TIMOLOL DERIVATIVES | INSITE VISION, INC. (US) | 1988-09-22 | — | — | WO | disclosed |
| EP-0008711-B1 | A METHOD OF PREPARING A 2-HYDROXY-3-ISOPROPYL OR A 2-HYDROXY-3-TERT-BUTYLAMINOPROPYL AROMATIC ETHER | SMITHKLINE BECKMAN CORPORATION (US) | 1981-11-04 | — | — | EP | disclosed |
| EP-0008711-A1 | A method of preparing a 2-hydroxy-3-isopropyl or a 2-hydroxy-3-tert-butylaminopropyl aromatic ether | SMITHKLINE BECKMAN CORPORATION (US) | 1980-03-19 | — | — | EP | disclosed |