Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | PTGDR2 | Q9Y5Y4 | 12/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.50 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2088770 | 0.90 | MEN1 (0.68) | MEN1KMT2AGAAUSP2POLB | |
| SCHEMBL2088767 | 0.90 | MEN1 (0.68) | MEN1KMT2AGAAUSP2POLB | |
| SCHEMBL5541138 | 0.87 | MEN1 (0.64) | MEN1KMT2AGAAUSP2POLB | |
| SCHEMBL5541148 | 0.87 | MEN1 (0.64) | MEN1KMT2AGAAUSP2POLB | |
| SCHEMBL2087574 | 0.84 | PTGDR2 (0.74) | MEN1KMT2AUSP2POLBPTGDR2 | |
| SCHEMBL5541065 | 0.82 | MEN1 (0.57) | MEN1KMT2AGAAUSP2POLB | |
| SCHEMBL5545284 | 0.81 | MEN1 (0.57) | MEN1KMT2AGAAUSP2POLB | |
| SCHEMBL5545279 | 0.81 | MEN1 (0.57) | MEN1KMT2AGAAUSP2POLB | |
| SCHEMBL2087279 | 0.81 | MEN1 (0.68) | MEN1KMT2AGAAUSP2POLB | |
| SCHEMBL2087281 | 0.81 | MEN1 (0.68) | MEN1KMT2AGAAUSP2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740171-A1 | INDOL-1-YL-ACETIC ACID DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005094816-A1 | INDOL-1-YL-ACETIC ACID DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2005-10-13 | — | — | WO | disclosed |