Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.39 |
| ▸ | MAPT | P10636 | 8/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5541560 | 1.00 | KCNH2 (0.58) | KCNH2PTGS1SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL5541554 | 1.00 | KCNH2 (0.58) | KCNH2PTGS1SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL6010892 | 0.91 | KCNH2 (0.57) | KCNH2PTGS1SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL6010897 | 0.88 | KCNH2 (0.54) | KCNH2PTGS1SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL6010900 | 0.88 | KCNH2 (0.54) | KCNH2PTGS1SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL5541521 | 0.88 | PTGS1 (0.65) | KCNH2PTGS1SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL5541530 | 0.88 | PTGS1 (0.65) | KCNH2PTGS1SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL5535416 | 0.87 | KCNH2 (0.57) | KCNH2PTGS1SLC6A2SLC6A4LMNA | |
| SCHEMBL5535402 | 0.87 | KCNH2 (0.57) | KCNH2PTGS1SLC6A2SLC6A4LMNA | |
| SCHEMBL5535406 | 0.87 | KCNH2 (0.57) | KCNH2PTGS1SLC6A2SLC6A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2570418-A2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-03-20 | — | — | EP | disclosed |
| EP-1555267-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLES | OTSUKA PHARMA CO LTD (JP) | 2013-01-16 | — | — | EP | disclosed |
| US-7262212-B2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-08-28 | — | — | US | disclosed |
| EP-1555267-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-07-20 | — | — | EP | disclosed |