SCHEMBL5542922

SCHEMBL5542922

CN1CCc2nc(C(=O)NCC(NC(=O)O)c3ccccc3)sc2C1

nearest known ligand 0.53

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ F10 P00742 19/20 0.53
▸ PRMT5 O14744 1/20 0.52
▸ WDR77 Q9BQA1 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5549587 0.83 F10 (0.53) F10PRMT5WDR77
SCHEMBL14497085 0.83 F10 (0.61) F10
Hydrochloric Acid SCHEMBL5541384 0.82 F10 (0.60) F10
SCHEMBL14496746 0.81 F10 (0.61) F10
Hydrochloric Acid SCHEMBL5548162 0.80 F10 (0.60) F10
SCHEMBL5548187 0.79 F10 (0.49) F10PRMT5WDR77
SCHEMBL5545023 0.78 F10 (0.47) F10PRMT5WDR77
SCHEMBL741569 0.78 F10 (0.56) F10PRMT5WDR77
SCHEMBL14515121 0.77 F10 (0.66) F10PRMT5WDR77
SCHEMBL14496965 0.76 F10 (0.52) F10PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070129371-A1 Novel ethylenediamine derivatives DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2007-06-07 — — US disclosed
EP-1577302-A1 NOVEL ETHYLENEDIAMINE DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2005-09-21 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070129371-A1 Novel ethylenediamine derivatives C1R, C9, C1S F10 238/4885PRMT5 1309/4885WDR77 2419/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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