Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 13/20 | 0.81 |
| ▸ | SLC6A3 | Q01959 | 13/20 | 0.81 |
| ▸ | SLC6A2 | P23975 | 12/20 | 0.81 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.59 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA4 | P22748 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2951055 | 0.90 | SLC6A4 (1.00) | SLC6A4SLC6A3SLC6A2CYP2D6CA1 | |
| SCHEMBL2952322 | 0.88 | SLC6A4 (0.79) | SLC6A4SLC6A3SLC6A2CYP2D6CA1 | |
| SCHEMBL588656 | 0.86 | SLC6A4 (0.81) | SLC6A4SLC6A3SLC6A2CYP2D6CA1 | |
| SCHEMBL6658178 | 0.86 | SLC6A4 (0.81) | SLC6A4SLC6A3SLC6A2CYP2D6MITF | |
| SCHEMBL588544 | 0.86 | SLC6A4 (0.81) | SLC6A4SLC6A3SLC6A2CYP2D6CA1 | |
| Hydrochloric Acid SCHEMBL588156 | 0.85 | SLC6A4 (0.79) | SLC6A4SLC6A3SLC6A2CYP2D6MITF | |
| Hydrochloric Acid SCHEMBL588157 | 0.85 | SLC6A4 (0.79) | SLC6A4SLC6A3SLC6A2CYP2D6MITF | |
| SCHEMBL2943412 | 0.83 | SLC6A4 (0.75) | SLC6A4SLC6A3SLC6A2CYP2D6ADRB1 | |
| SCHEMBL2952327 | 0.83 | SLC6A4 (1.00) | SLC6A4SLC6A3SLC6A2CYP2D6CA1 | |
| SCHEMBL2950159 | 0.81 | SLC6A4 (0.72) | SLC6A4SLC6A3SLC6A2CYP2D6MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751131-A1 | MTP INHIBITING ARYL PIPERIDINES OR PIPERAZINES SUBSTITUTED WITH 5-MEMBERED HETEROCYCLES | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005085226-A1 | MTP INHIBITING ARYL PIPERIDINES OR PIPERAZINES SUBSTITUTED WITH 5-MEMBERED HETEROCYCLES | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-09-15 | — | — | WO | disclosed |