Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.39 |
| ▸ | ITGAL | P20701 | 3/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5537162 | 0.91 | SMN1; SMN2 (0.48) | GPR183NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL5534983 | 0.81 | KCNH2 (0.49) | NPC1RAB9AALDH1A1SMN1; SMN2KCNH2 | |
| SCHEMBL5540651 | 0.81 | KCNH2 (0.49) | NPC1RAB9AALDH1A1SMN1; SMN2KCNH2 | |
| SCHEMBL5544246 | 0.81 | KCNH2 (0.43) | NPC1RAB9AALDH1A1KCNH2CACNA1C | |
| SCHEMBL4442211 | 0.79 | KCNH2 (0.51) | ALDH1A1SMN1; SMN2KCNH2CACNA1CSCN5A | |
| SCHEMBL4441674 | 0.79 | KCNH2 (0.51) | ALDH1A1SMN1; SMN2KCNH2CACNA1CSCN5A | |
| SCHEMBL4441668 | 0.79 | KCNH2 (0.51) | ALDH1A1SMN1; SMN2KCNH2CACNA1CSCN5A | |
| Fumaric Acid SCHEMBL5545101 | 0.79 | KCNH2 (0.48) | ALDH1A1SMN1; SMN2KCNH2CACNA1CSCN5A | |
| Maleic Acid SCHEMBL5545089 | 0.79 | KCNH2 (0.48) | ALDH1A1SMN1; SMN2KCNH2CACNA1CSCN5A | |
| Fumaric Acid SCHEMBL5545106 | 0.79 | KCNH2 (0.48) | ALDH1A1SMN1; SMN2KCNH2CACNA1CSCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2570418-A2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-03-20 | — | — | EP | disclosed |
| EP-1555267-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLES | OTSUKA PHARMA CO LTD (JP) | 2013-01-16 | — | — | EP | disclosed |
| US-7262212-B2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-08-28 | — | — | US | disclosed |
| US-20060094767-A1 | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-05-04 | — | — | US | disclosed |
| EP-1555267-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-07-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094767-A1 | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | NR2C2, NR4A3, NR4A2 | GPR183 409/4885NPC1 2404/4885RAB9A 2824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.