Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.56 |
| ▸ | DRD3 | P35462 | 8/20 | 0.52 |
| ▸ | DRD2 | P14416 | 6/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5023032 | 0.96 | HRH3 (0.54) | HRH3DRD3DRD2HRH4AKR1C3 | |
| SCHEMBL5023291 | 0.96 | HRH3 (0.55) | HRH3DRD3DRD2HRH4AKR1C3 | |
| SCHEMBL5024341 | 0.93 | HRH3 (0.61) | HRH3DRD3DRD2HRH4NPC1 | |
| SCHEMBL5017210 | 0.92 | HRH3 (0.60) | HRH3DRD3DRD2HRH4NPC1 | |
| SCHEMBL5025926 | 0.92 | HRH3 (0.60) | HRH3DRD3DRD2HRH4NPC1 | |
| SCHEMBL5016999 | 0.91 | HRH3 (0.61) | HRH3DRD3DRD2HRH4NPC1 | |
| SCHEMBL5025949 | 0.88 | HRH3 (0.71) | HRH3DRD3DRD2HRH4AKR1C3 | |
| SCHEMBL5017140 | 0.87 | HRH4 (0.62) | HRH3DRD3DRD2HRH4NPC1 | |
| SCHEMBL5017096 | 0.87 | HRH3 (0.58) | HRH3DRD3DRD2HRH4AKR1C3 | |
| SCHEMBL5024291 | 0.87 | HRH3 (0.60) | HRH3DRD3DRD2HRH4AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761519-A1 | INDOLE DERIVATIVES AS HISTAMINE RECEPTOR ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | disclosed |
| WO-2005123716-A1 | INDOLE DERIVATIVES AS HISTAMINE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-29 | — | — | WO | disclosed |