Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 17/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL435172 | 0.91 | PDE4B (0.56) | PDE4BPDE4APDE4DTAS1R3TAS1R1 | |
| SCHEMBL4886574 | 0.91 | PDE4B (0.56) | PDE4BPDE4APDE4DTAS1R3TAS1R1 | |
| SCHEMBL5552570 | 0.91 | PDE4B (0.48) | PDE4BPDE4APDE4DTAS1R3TAS1R1 | |
| SCHEMBL4182884 | 0.89 | PDE4B (0.50) | PDE4BPDE4APDE4DHPGD | |
| SCHEMBL13929105 | 0.89 | PDE4B (0.50) | PDE4BPDE4APDE4DHPGD | |
| SCHEMBL8303245 | 0.89 | PDE4B (0.50) | PDE4BPDE4APDE4DHPGD | |
| SCHEMBL4187256 | 0.89 | PDE4B (0.45) | PDE4BPDE4APDE4DHPGDCYP3A4 | |
| SCHEMBL13929027 | 0.89 | PDE4B (0.43) | PDE4BPDE4APDE4DHPGD | |
| SCHEMBL13929009 | 0.89 | PDE4B (0.45) | PDE4BPDE4APDE4DHPGDCYP3A4 | |
| SCHEMBL4186392 | 0.89 | PDE4B (0.43) | PDE4BPDE4APDE4DHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651640-B1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LTD (GB) | 2007-02-14 | — | — | EP | disclosed |
| US-20060178408-A1 | Nicotinamide derivatives useful as pde4 inhibitors | BARBER CHRISTOPHER G | 2006-08-10 | — | — | US | disclosed |
| US-20050043326-A1 | Compounds | PFIZER INC | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178408-A1 | Nicotinamide derivatives useful as pde4 inhibitors | PDE4A, PDE4B, PDE4C | PDE4B 2/4885PDE4A 1/4885PDE4D 5/4885 |
| US-20050043326-A1 | Compounds | NQO1, NAMPT, NNT | PDE4B 719/4885PDE4A 1024/4885PDE4D 1102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.