Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 4/20 | 0.40 |
| ▸ | CNR2 | P34972 | 4/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ABHD12 | Q8N2K0 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5551262 | 0.90 | PDE4A (0.42) | PDE4BPDE4DPDE4ACNR1CRHR1 | |
| SCHEMBL13929064 | 0.82 | SMYD3 (0.49) | PDE4BPDE4DPDE4ATYK2CNR2 | |
| Hydrochloric Acid SCHEMBL4200643 | 0.81 | SMYD3 (0.48) | PDE4BPDE4DPDE4ATYK2CNR2 | |
| SCHEMBL4184529 | 0.80 | KDM5A (0.43) | PDE4BPDE4DPDE4ATYK2CNR2 | |
| SCHEMBL13929020 | 0.80 | KDM5A (0.43) | PDE4BPDE4DPDE4ATYK2CNR2 | |
| SCHEMBL5547933 | 0.79 | PDE4B (0.55) | PDE4BPDE4DPDE4ACNR2CNR1 | |
| SCHEMBL4198559 | 0.79 | TYK2 (0.43) | PDE4BPDE4DPDE4ATYK2CNR2 | |
| SCHEMBL8303269 | 0.79 | TYK2 (0.43) | PDE4BPDE4DPDE4ATYK2CNR2 | |
| SCHEMBL5754512 | 0.77 | PDE4B (0.53) | PDE4BPDE4DPDE4AKCNH2 | |
| SCHEMBL4886574 | 0.76 | PDE4B (0.56) | PDE4BPDE4DPDE4ATYK2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651640-B1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LTD (GB) | 2007-02-14 | — | — | EP | disclosed |
| US-20060178408-A1 | Nicotinamide derivatives useful as pde4 inhibitors | BARBER CHRISTOPHER G | 2006-08-10 | — | — | US | disclosed |
| US-20050043326-A1 | Compounds | PFIZER INC | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178408-A1 | Nicotinamide derivatives useful as pde4 inhibitors | PDE4A, PDE4B, PDE4C | PDE4B 2/4885PDE4D 5/4885PDE4A 1/4885 |
| US-20050043326-A1 | Compounds | NQO1, NAMPT, NNT | PDE4B 719/4885PDE4D 1102/4885PDE4A 1024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.