Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KLK7 | P49862 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4173715 | 1.00 | MAPT (0.38) | MAPTKLK7ALOX15ALDH1A1CHRM4 | |
| SCHEMBL4178166 | 1.00 | MAPT (0.38) | MAPTKLK7ALOX15ALDH1A1CHRM4 | |
| SCHEMBL4181353 | 0.84 | KDM1A (0.36) | MAPTGAANPY1RSLC6A4KCNH2 | |
| SCHEMBL5548255 | 0.84 | KDM1A (0.36) | MAPTGAANPY1RSLC6A4KCNH2 | |
| SCHEMBL4175835 | 0.79 | KDM1A (0.35) | ALDH1A1GAANPY1RSLC6A4KCNH2 | |
| SCHEMBL4068879 | 0.70 | KDM1A (0.42) | ALDH1A1NPY1RSLC6A4KCNH2MEN1 | |
| SCHEMBL4887081 | 0.70 | KDM1A (0.42) | ALDH1A1NPY1RSLC6A4KCNH2MEN1 | |
| SCHEMBL3083828 | 0.70 | KDM1A (0.42) | ALDH1A1NPY1RSLC6A4KCNH2MEN1 | |
| SCHEMBL14566706 | 0.70 | KDM1A (0.42) | ALDH1A1NPY1RSLC6A4KCNH2MEN1 | |
| SCHEMBL22578210 | 0.66 | CXCR4 (0.40) | ALDH1A1CHRM4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853604-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006096444-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-09-14 | — | — | WO | disclosed |