Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | UBE2M | P61081 | 3/20 | 0.33 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | ARG1 | P05089 | 1/20 | 0.32 |
| ▸ | ARG2 | P78540 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5547597 | 1.00 | KCNH2 (0.45) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL6010780 | 0.93 | KCNH2 (0.46) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL6010794 | 0.93 | KCNH2 (0.46) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL6010603 | 0.91 | KCNH2 (0.43) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL6010606 | 0.85 | KCNH2 (0.44) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL5537931 | 0.85 | KCNH2 (0.47) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL5537936 | 0.85 | KCNH2 (0.47) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL6010998 | 0.84 | KCNH2 (0.59) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL6010995 | 0.84 | KCNH2 (0.59) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL6010905 | 0.84 | PTGS1 (0.52) | KCNH2CACNA1CSCN5APTGS1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2570418-A2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-03-20 | — | — | EP | disclosed |
| EP-1555267-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLES | OTSUKA PHARMA CO LTD (JP) | 2013-01-16 | — | — | EP | disclosed |
| US-7262212-B2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-08-28 | — | — | US | disclosed |
| EP-1555267-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-07-20 | — | — | EP | disclosed |