Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 7/20 | 0.80 |
| ▸ | CACNA1B | Q00975 | 7/20 | 0.80 |
| ▸ | CACNB1 | Q02641 | 7/20 | 0.80 |
| ▸ | CACNA1C | Q13936 | 7/20 | 0.80 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.56 |
| ▸ | CNR1 | P21554 | 1/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | GHSR | Q92847 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5548263 | 0.89 | CACNA2D1 (1.00) | CACNA2D1CACNA1BCACNB1CACNA1CMEN1 | |
| SCHEMBL5549056 | 0.85 | CACNA2D1 (1.00) | CACNA2D1CACNA1BCACNB1CACNA1CMEN1 | |
| SCHEMBL5549075 | 0.84 | CACNA2D1 (0.80) | CACNA2D1CACNA1BCACNB1CACNA1CMEN1 | |
| SCHEMBL5547408 | 0.82 | CACNA2D1 (0.65) | CACNA2D1CACNA1BCACNB1CACNA1CMEN1 | |
| SCHEMBL5541417 | 0.80 | CACNA2D1 (1.00) | CACNA2D1CACNA1BCACNB1CACNA1CMEN1 | |
| SCHEMBL5547410 | 0.80 | CACNA2D1 (0.80) | CACNA2D1CACNA1BCACNB1CACNA1CMEN1 | |
| SCHEMBL5543951 | 0.78 | CACNA2D1 (0.73) | CACNA2D1CACNA1BCACNB1CACNA1CMEN1 | |
| SCHEMBL5541435 | 0.78 | CACNA2D1 (1.00) | CACNA2D1CACNA1BCACNB1CACNA1CMEN1 | |
| SCHEMBL6498386 | 0.77 | CACNA2D1 (0.80) | CACNA2D1CACNA1BCACNB1CACNA1CMEN1 | |
| SCHEMBL5547473 | 0.77 | CACNA2D1 (0.76) | CACNA2D1CACNA1BCACNB1CACNA1CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745042-A1 | DIARYLAMINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Neuromed Pharmaceuticals, Ltd. (CA) | 2007-01-24 | — | — | EP | claimed |
| WO-2005097779-A1 | DIARYLAMINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2005-10-20 | — | — | WO | claimed |
| US-20050227999-A1 | Diarylamine derivatives as calcium channel blockers | NEUROMED TECHNOLOGIES INC. | 2005-10-13 | — | — | US | claimed |
| US-20050227999-A1 | Diarylamine derivatives as calcium channel blockers | NEUROMED TECHNOLOGIES INC. | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227999-A1 | Diarylamine derivatives as calcium channel blockers | ORAI1, CACNA1D, CACNA1C | CACNA2D1 51/4885CACNA1B 4/4885CACNB1 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.