Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 7/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3632658 | 0.83 | CHRM5 (0.45) | SMN1; SMN2ALDH1A1CHRM5CHRM3KMT2A | |
| SCHEMBL18354053 | 0.72 | TOP2A (0.42) | SMN1; SMN2TSHRPOLBALDH1A1THRB | |
| SCHEMBL7361998 | 0.72 | TSHR (0.38) | SMN1; SMN2TSHRPOLBALDH1A1THRB | |
| SCHEMBL25274359 | 0.71 | TOP2A (0.45) | SMN1; SMN2TSHRPOLBALDH1A1THRB | |
| SCHEMBL8826610 | 0.71 | TOP2A (0.45) | SMN1; SMN2TSHRPOLBALDH1A1THRB | |
| SCHEMBL9967746 | 0.71 | PIK3CD (0.55) | SMN1; SMN2TSHRALDH1A1THRBTOP2A | |
| SCHEMBL5504851 | 0.70 | TSHR (0.39) | SMN1; SMN2TSHRPOLBALDH1A1THRB | |
| SCHEMBL16233027 | 0.69 | SMN1; SMN2 (0.48) | SMN1; SMN2TSHRPOLBALDH1A1THRB | |
| SCHEMBL8276616 | 0.69 | TOP2A (0.39) | SMN1; SMN2TSHRTHRBTOP2ATOP2B | |
| SCHEMBL24739921 | 0.69 | CHRM5 (0.67) | SMN1; SMN2POLBALDH1A1TOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846411-A2 | ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006081289-A2 | ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2006-08-03 | — | — | WO | disclosed |