Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7860312 | 0.94 | — | — | |
| Potassium Ion SCHEMBL553768 | 0.94 | SLC34A1 (0.32) | — | |
| SCHEMBL920065 | 0.94 | — | — | |
| SCHEMBL4823616 | 0.94 | — | — | |
| Lithium Ion SCHEMBL21749348 | 0.94 | — | — | |
| SCHEMBL553542 | 0.94 | — | — | |
| Water SCHEMBL28672424 | 0.91 | SLC34A1 (0.30) | — | |
| Tetramethylammonium Ion SCHEMBL1758243 | 0.88 | — | — | |
| Potassium Ion SCHEMBL18394942 | 0.75 | SLC34A1 (0.32) | — | |
| Lithium Ion SCHEMBL21749343 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108456194-B | Triazole antibacterial derivative, and pharmaceutical composition and application thereof | 武汉朗来科技发展有限公司 | 2021-06-22 | — | — | CN | disclosed |
| US-11040958-B2 | Triazole antimicrobial derivative, pharmaceutical composition and use thereof | WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD. (CN) | 2021-06-22 | — | — | US | disclosed |
| CN-107033186-B | Posaconazole derivatives, pharmaceutical compositions and uses thereof | 武汉朗来科技发展有限公司 | 2020-06-09 | — | — | CN | disclosed |
| US-20190038621-A1 | POSACONAZOLE DERIVATIVE, PHARMACEUTICAL COMPOSITION AND USE THEREOF | WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD. (CN) | 2019-02-07 | — | — | US | disclosed |
| CN-105367482-B | N acyl sulfonamides apoptosis accelerator | 阿斯利康(瑞典)有限公司 | 2017-12-12 | — | — | CN | disclosed |
| US-20160176906-A1 | Chemical Compounds | ASTRAZENECA AB (SE) | 2016-06-23 | — | — | US | disclosed |
| CN-105367482-A | N-acylsulfamide apoptosis accelerator | ASTRAZENECA AB | 2016-03-02 | — | — | CN | disclosed |
| US-9248140-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2016-02-02 | — | — | US | disclosed |
| CN-103153954-B | N-acylsulfonamide apoptosis promoters | ASTRAZENECA AB (SE) | 2015-11-25 | — | — | CN | disclosed |
| US-20150328239-A1 | Chemical Compounds | ASTRAZENECA AB (SE) | 2015-11-19 | — | — | US | disclosed |
| WO-2002042283-A1 | IMPROVED PROCESS FOR WATER SOLUBLE AZOLE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-05-30 | — | — | WO | disclosed |
| US-20020062028-A1 | Process for water soluble azole compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2002-05-23 | — | — | US | disclosed |
| US-6362172-B2 | (DIHYDROGEN PHOSPHONOXY)ALKYLOXY CONTAINING A TRIAZOLE DERIVATIVE USED AS ANTIFUNGAL AGENT | BRISTOL-MYERS SQUIBB COMPANY | 2002-03-26 | — | — | US | disclosed |
| US-20010041691-A1 | Water soluble prodrugs of azole compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2001-11-15 | — | — | US | disclosed |
| US-20010016662-A1 | Water-soluble prodrugs of azole compounds | GOLIK JERZY (US) | 2001-08-23 | — | — | US | disclosed |
| US-20010014742-A1 | Water-soluble prodrugs of azole compounds | GOLIK JERZY (US) | 2001-08-16 | — | — | US | disclosed |
| WO-2001052852-A1 | WATER SOLUBLE PRODRUGS OF AZOLE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-07-26 | — | — | WO | disclosed |
| US-6235728-B1 | FUNGICIDES | BRISTOL-MYERS SQUIBB COMPANY | 2001-05-22 | — | — | US | disclosed |
| US-5310648-A | Polymer-metal chelate compound | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 1994-05-10 | — | — | US | disclosed |
| WO-1992013447-A1 | TEMPLATE POLYMERIZATION USING METAL CHELATES AND FLUID IMPRINT MATRICES | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 1992-08-20 | — | — | WO | disclosed |