Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 8/20 | 0.51 |
| ▸ | LMNA | P02545 | 7/20 | 0.51 |
| ▸ | POLB | P06746 | 4/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 7/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5549172 | 0.86 | S1PR1 (0.49) | TOP1LMNAALDH1A1 | |
| SCHEMBL5550107 | 0.85 | TOP1 (0.66) | TOP1LMNA | |
| 7-Desethyl-Norfloxacin SCHEMBL5551203 | 0.84 | TOP1 (0.70) | TOP1HPGDLMNAPOLBTAAR1 | |
| 7-Desethyl-Norfloxacin SCHEMBL30610053 | 0.84 | TOP1 (0.70) | TOP1HPGDLMNAPOLBTAAR1 | |
| SCHEMBL16591589 | 0.83 | KDM4E (0.45) | TOP1HPGDLMNAPOLBTAAR1 | |
| 7-Desethyl-Norfloxacin SCHEMBL29548802 | 0.83 | TOP1 (0.68) | TOP1HPGDLMNAPOLBTAAR1 | |
| SCHEMBL5549161 | 0.80 | TOP1 (0.56) | TOP1HPGDLMNAPOLBTAAR1 | |
| SCHEMBL5550927 | 0.80 | KDM4E (0.50) | HPGDLMNAKDM4EALDH1A1HSD17B10 | |
| SCHEMBL10993573 | 0.79 | KDM4E (0.57) | HPGDLMNAPOLBTAAR1KDM4E | |
| SCHEMBL9148055 | 0.79 | KDM4E (0.57) | HPGDLMNAPOLBTAAR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453846-B1 | 14 OR 15 MEMBERED MACROLIDES WITH ANTIBACTERIAL ACTIVITY | GLAXO GROUP LTD (GB) | 2007-05-16 | — | — | EP | disclosed |
| US-7202221-B2 | Macrolides | GLAXO GROUP LIMITED (GB) | 2007-04-10 | — | — | US | disclosed |
| CN-1307194-C | Macrolides | GLAXO GROUP LTD (GB) | 2007-03-28 | — | — | CN | disclosed |
| CN-1612888-A | Macrolides | GLAXO GROUP LTD (GB) | 2005-05-04 | — | — | CN | disclosed |
| US-20050080025-A1 | Macrolides | PLIVA D.D. (HR) | 2005-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080025-A1 | Macrolides | IL17A, CYP51A1, IL15 | TOP1 1909/4885HPGD 2437/4885LMNA 1397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.