Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | PAK4 | O96013 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.56 |
| ▸ | PRKACA | P17612 | 1/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
| ▸ | LTK | P29376 | 1/20 | 0.56 |
| ▸ | GRK5 | P34947 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.56 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.56 |
| ▸ | CDK8 | P49336 | 1/20 | 0.56 |
| ▸ | CLK2 | P49760 | 1/20 | 0.56 |
| ▸ | GSK3A | P49840 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2012989 | 0.90 | HDAC1 (0.54) | CHEK1AURKADAPK3PRKD3MAP4K4 | |
| SCHEMBL7621269 | 0.80 | CDK8 (0.65) | CHEK1AURKADAPK3PRKD3MAP4K4 | |
| SCHEMBL162420 | 0.80 | CDK8 (0.65) | CHEK1AURKADAPK3PRKD3MAP4K4 | |
| SCHEMBL30980399 | 0.80 | CDK8 (0.65) | CHEK1AURKADAPK3PRKD3MAP4K4 | |
| SCHEMBL15246624 | 0.79 | NAMPT (0.69) | NAMPT | |
| SCHEMBL15246460 | 0.76 | NAMPT (0.75) | NAMPT | |
| SCHEMBL11573210 | 0.76 | NAMPT (0.69) | CHEK1AURKADAPK3PRKD3MAP4K4 | |
| SCHEMBL13977223 | 0.75 | DYRK1A (0.71) | CHEK1AURKADAPK3PRKD3MAP4K4 | |
| SCHEMBL15530345 | 0.75 | NAMPT (0.78) | NAMPT | |
| SCHEMBL842776 | 0.74 | GSK3B (0.60) | CHEK1AURKADAPK3PRKD3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753428-A2 | KINASE INHIBITORS AS THERAPEUTIC AGENTS | Abbott Laboratories (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005110410-A2 | KINASE INHIBITORS AS THERAPEUTIC AGENTS | ABBOTT LABORATORIES (US) | 2005-11-24 | — | — | WO | disclosed |