Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | CDC42 | P60953 | 1/20 | 0.51 |
| ▸ | RAC1 | P63000 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.51 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30892259 | 1.00 | TDP1 (0.55) | TDP1L3MBTL1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL722654 | 1.00 | TDP1 (0.55) | TDP1L3MBTL1PTGS2AKR1C3AKR1C2 | |
| Methane SCHEMBL27805211 | 0.98 | TDP1 (0.54) | TDP1L3MBTL1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL27783582 | 0.85 | TDP1 (0.43) | TDP1L3MBTL1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL4266625 | 0.85 | TDP1 (0.48) | TDP1L3MBTL1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL13067831 | 0.84 | TDP1 (0.49) | TDP1L3MBTL1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL6714731 | 0.84 | AKR1C3 (0.52) | TDP1L3MBTL1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL8212247 | 0.84 | AKR1C3 (0.52) | TDP1L3MBTL1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL11459746 | 0.83 | TDP1 (0.55) | TDP1L3MBTL1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL13448800 | 0.83 | TDP1 (0.55) | TDP1L3MBTL1PTGS2AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115322099-B | Naproxen-cinnamic acid derivative and application thereof in preparation of medicines for treating LPS-induced inflammation | 五邑大学 | 2024-04-02 | — | — | CN | claimed |
| CN-115322099-A | Naproxen-cinnamic acid derivatives and application thereof in preparation of drugs for treating LPS (LPS) -induced inflammation | 五邑大学 | 2022-11-11 | — | — | CN | claimed |
| CN-101735057-A | Naphthyl carboxylic acid compounds with insulin-sensitizing activity and preparation method thereof | SHANGHAI CIRUI MEDICAL TECHNOL | 2010-06-16 | — | — | CN | claimed |
| CN-115322099-B | Naproxen-cinnamic acid derivative and application thereof in preparation of medicines for treating LPS-induced inflammation | 五邑大学 | 2024-04-02 | — | — | CN | disclosed |
| CN-115322099-A | Naproxen-cinnamic acid derivatives and application thereof in preparation of drugs for treating LPS (LPS) -induced inflammation | 五邑大学 | 2022-11-11 | — | — | CN | disclosed |
| US-RE45548-E1 | Functionalized drugs and polymers derived therefrom | BEZWADA BIOMEDICAL, LLC (US) | 2015-06-09 | — | — | US | disclosed |
| US-RE45548-E1 | Functionalized drugs and polymers derived therefrom | BEZWADA BIOMEDICAL, LLC (US) | 2015-06-09 | — | — | US | disclosed |
| US-RE45548-E1 | Functionalized drugs and polymers derived therefrom | BEZWADA BIOMEDICAL, LLC (US) | 2015-06-09 | — | — | US | disclosed |
| US-8802892-B2 | Functionalized phenolic compounds and polymers therefrom | BEZWADA BIOMEDICAL, LLC (US) | 2014-08-12 | — | — | US | disclosed |
| US-8802892-B2 | Functionalized phenolic compounds and polymers therefrom | BEZWADA BIOMEDICAL, LLC (US) | 2014-08-12 | — | — | US | disclosed |
| US-8802892-B2 | Functionalized phenolic compounds and polymers therefrom | BEZWADA BIOMEDICAL, LLC (US) | 2014-08-12 | — | — | US | disclosed |
| US-4097674-A | ANTIINFLAMMATORY, ANTIPYRETIC, ANTIPRURITIC AGENTS, ANALGESICS | SYNTEX CORPORATION (US) | 1978-06-27 | — | — | US | disclosed |
| US-4051233-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC, ANTIPRURITIC | SYNTEX CORPORATION (US) | 1977-09-27 | — | — | US | disclosed |
| US-4048330-A | Compositions containing 2-(6'-substituted-2'-naphthyl)acetic acid esters used for treating inflammation, pain or pyrexia | SYNTEX CORPORATION (US) | 1977-09-13 | — | — | US | disclosed |
| US-4009197-A | 2-(6-Substituted-2'-naphthyl) acetic acid derivatives and the salts and esters thereof | SYNTEX CORPORATION (PM) | 1977-02-22 | — | — | US | disclosed |
| US-4001301-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIPYRETICS, ANTI-PRURITIC | SYNTEX CORPORATION (PM) | 1977-01-04 | — | — | US | disclosed |
| US-3998966-A | Anti-inflammatory, analgesic, anti-pyretic and anti-pruritic 6-substituted 2-naphthyl acetic acid derivative-containing compositions and methods of use thereof | SYNTEX CORPORATION (PM) | 1976-12-21 | — | — | US | disclosed |
| US-3980699-A | ANTIINFLAMMATORY, ANALGESICS, ANTIPYRETIC, ANTIPRURITIC | SYNTEX CORPORATION (PM) | 1976-09-14 | — | — | US | disclosed |
| US-3978124-A | ANALGESIC, ANTIPYRETIC | SYNTEX CORPORATION (PM) | 1976-08-31 | — | — | US | disclosed |
| US-3978116-A | ANALGESIC, ANTIPYRETIC | SYNTEX CORPORATION (PM) | 1976-08-31 | — | — | US | disclosed |