⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethyl Nitrite [Spirit] SCHEMBL132415 | 0.96 | — | — | |
| Ethyl Nitrite [Spirit] SCHEMBL5331030 | 0.96 | KMT2A (1.00) | — | |
| Ethyl Nitrite [Spirit] SCHEMBL28151734 | 0.93 | — | — | |
| Ethyl Nitrite [Spirit] SCHEMBL4019121 | 0.93 | — | — | |
| Ethyl Nitrite [Spirit] SCHEMBL27528340 | 0.93 | — | — | |
| Ethyl Nitrite [Spirit] SCHEMBL27996522 | 0.90 | — | — | |
| Ethyl Nitrite [Spirit] SCHEMBL21056441 | 0.87 | — | — | |
| Ethyl Nitrite [Spirit] SCHEMBL15011675 | 0.87 | — | — | |
| Ethyl Nitrite [Spirit] SCHEMBL28250098 | 0.87 | KMT2A (0.81) | — | |
| Ethyl Nitrite [Spirit] SCHEMBL27679816 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871506-B2 | Methods for treating cardio pulmonary diseases with NO group compounds | DUKE UNIVERSITY (US) | 2014-10-28 | — | — | US | disclosed |
| US-20130210136-A1 | Methods For Treating Cardio Pulmonary Diseases With NO Group Compounds | DUKE UNIVERSITY (US) | 2013-08-15 | — | — | US | disclosed |
| US-20070191478-A1 | Methods of treating cardio pulmonary diseases with NO group compounds | DUKE UNIVERSITY | 2007-08-16 | — | — | US | disclosed |
| US-6945247-B1 | Method of treating cardio pulmonary diseases with no group compounds | DUKE UNIVERSITY (US) | 2005-09-20 | — | — | US | disclosed |
| EP-1229954-A4 | METHOD OF TREATING CARDIO PULMONARY DISEASES WITH NO GROUP COMPOUNDS | UNIV DUKE (US) | 2005-05-25 | — | — | EP | disclosed |
| EP-1229954-A1 | METHOD OF TREATING CARDIO PULMONARY DISEASES WITH NO GROUP COMPOUNDS | DUKE UNIVERSITY (US) | 2002-08-14 | — | — | EP | disclosed |
| US-6314956-B1 | TREATING LUNG DEFECTS ASSOCIATED HYPOXEMIA OR SMOOTH MUSCLE CONSTRICTION; ADMINISTER ETHYL NITRITE TO HUMAN AND MONITOR | DUKE UNIVERSITY | 2001-11-13 | — | — | US | disclosed |
| WO-2001017596-A1 | METHOD OF TREATING CARDIO PULMONARY DISEASES WITH NO GROUP COMPOUNDS | DUKE UNIVERSITY (US) | 2001-03-15 | — | — | WO | disclosed |