Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 6/20 | 0.38 |
| ▸ | CIT | O14578 | 1/20 | 0.37 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | STK10 | O94804 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | YES1 | P07947 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | HCK | P08631 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | FGR | P09769 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5550505 | 0.82 | KDR (0.41) | AURKARPS6KB1KDRCITMAP3K7 | |
| SCHEMBL446028 | 0.79 | KDR (0.49) | AURKARPS6KB1KDRCITMAP3K7 | |
| SCHEMBL428190 | 0.71 | KDR (0.56) | AURKARPS6KB1KDRCITMAP3K7 | |
| SCHEMBL428299 | 0.71 | KDR (0.45) | AURKARPS6KB1KDRCITMAP3K7 | |
| SCHEMBL428215 | 0.70 | KDR (0.56) | AURKARPS6KB1KDRCITMAP3K7 | |
| SCHEMBL446007 | 0.69 | KDR (0.40) | AURKARPS6KB1KDRCITMAP3K7 | |
| SCHEMBL27568457 | 0.69 | KDR (0.41) | AURKARPS6KB1KDRCITMAP3K7 | |
| SCHEMBL428281 | 0.68 | MAPT (0.65) | AURKARPS6KB1KDRABL1EGFR | |
| SCHEMBL3141548 | 0.68 | KDR (0.47) | AURKARPS6KB1KDRFLT1AURKB | |
| SCHEMBL447437 | 0.67 | KDR (0.51) | AURKARPS6KB1KDRCITMAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1798230-A1 | Substituted alkylamine derivatives and methods of use | Amgen Inc. (US) | 2007-06-20 | — | — | EP | disclosed |