Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 20/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5547393 | 0.91 | CHEK1 (0.80) | CHEK1 | |
| SCHEMBL143237 | 0.90 | CHEK1 (1.00) | CHEK1 | |
| SCHEMBL14402837 | 0.89 | CHEK1 (0.80) | CHEK1 | |
| SCHEMBL5548469 | 0.87 | CHEK1 (0.81) | CHEK1 | |
| SCHEMBL5552872 | 0.87 | CHEK1 (0.76) | CHEK1 | |
| SCHEMBL14402831 | 0.87 | CHEK1 (1.00) | CHEK1 | |
| SCHEMBL5548386 | 0.83 | CHEK1 (0.70) | CHEK1 | |
| SCHEMBL5551287 | 0.82 | CHEK1 (0.72) | CHEK1 | |
| SCHEMBL14402851 | 0.78 | CHEK1 (0.78) | CHEK1 | |
| SCHEMBL5137424 | 0.78 | CHEK1 (0.78) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007084135-A9 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO INC (US) | 2007-10-11 | — | — | WO | disclosed |
| WO-2007084135-A9 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO INC (US) | 2007-10-11 | — | — | WO | disclosed |