⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5552278 | 0.78 | TSHR (0.38) | — | |
| SCHEMBL5913624 | 0.75 | — | — | |
| SCHEMBL36671 | 0.73 | — | — | |
| SCHEMBL1936262 | 0.73 | TSHR (0.40) | — | |
| SCHEMBL4367765 | 0.73 | TSHR (0.40) | — | |
| SCHEMBL11352534 | 0.73 | — | — | |
| SCHEMBL27383791 | 0.73 | — | — | |
| Bicarbonate SCHEMBL6046315 | 0.71 | TSHR (0.53) | — | |
| SCHEMBL2159669 | 0.71 | — | — | |
| SCHEMBL3690443 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230381324-A1 | SMALL MOLECULE DRUG CONJUGATES | EIDGENOESSICHE TECHNISCHE HOCHSCHULE ZURICH (CH) | 2023-11-30 | — | — | US | disclosed |
| EP-3928796-A1 | SMALL MOLECULE DRUG CONJUGATES | Eidgenöessische Technische Hochschule Zurich (CH) | 2021-12-29 | — | — | EP | disclosed |
| US-20210308269-A1 | Small Molecule Drug Conjugates | EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH (CH) | 2021-10-07 | — | — | US | disclosed |
| EP-3730154-B1 | SMALL MOLECULE DRUG CONJUGATES | EIDGENOESSICHE TECHNISCHE HOCHSCHULE ZUERICH (CH) | 2021-06-30 | — | — | EP | disclosed |
| EP-3424537-B1 | SMALL MOLECULE DRUG CONJUGATES | EIDGENOESSICHE TECHNISCHE HOCHSCHULE ZUERICH (CH) | 2021-01-13 | — | — | EP | disclosed |
| EP-3730154-A1 | SMALL MOLECULE DRUG CONJUGATES | Eidgenössiche Technische Hochschule Zürich (CH) | 2020-10-28 | — | — | EP | disclosed |
| EP-3424537-A1 | SMALL MOLECULE DRUG CONJUGATES | Eidgenössiche Technische Hochschule Zürich (CH) | 2019-01-09 | — | — | EP | disclosed |
| US-20180280523-A1 | Small Molecule Drug Conjugates | ETH-ZURICH (CH) | 2018-10-04 | — | — | US | disclosed |
| WO-2018154517-A1 | IMMUNOCYTOKINE COMBINATION THERAPY | PHILOGEN SPA (IT) | 2018-08-30 | — | — | WO | disclosed |
| US-10016511-B2 | Small molecule drug conjugates | ETH ZURICH (CH) | 2018-07-10 | — | — | US | disclosed |
| US-8278264-B2 | Compositions and methods for enhancing drug delivery across and into ocular tissues | KAI PHARMACEUTICALS, INC. (US) | 2012-10-02 | — | — | US | disclosed |
| US-20070213277-A1 | Compositions and methods for enhancing drug delivery across and into ocular tissues | CELLGATE, INC., A DELAWARE CORPORATION | 2007-09-13 | — | — | US | disclosed |
| EP-1367995-A4 | COMPOSITIONS AND METHODS FOR ENHANCING DRUG DELIVERY ACROSS AND INTO EPITHELIAL TISSUES | CELLGATE INC (US) | 2007-08-01 | — | — | EP | disclosed |
| EP-1372626-A4 | COMPOSITIONS AND METHODS FOR ENHANCING DRUG DELIVERY ACROSS AND INTO OCULAR TISSUES | CELLGATE INC (US) | 2007-08-01 | — | — | EP | disclosed |
| US-7229961-B2 | Compositions and methods for enhancing drug delivery across and into ocular tissues | CELLGATE, INC. (US) | 2007-06-12 | — | — | US | disclosed |
| EP-1372626-A1 | COMPOSITIONS AND METHODS FOR ENHANCING DRUG DELIVERY ACROSS AND INTO OCULAR TISSUES | Cellgate Inc. (US) | 2004-01-02 | — | — | EP | disclosed |
| EP-1367995-A1 | COMPOSITIONS AND METHODS FOR ENHANCING DRUG DELIVERY ACROSS AND INTO EPITHELIAL TISSUES | Cellgate Inc. (US) | 2003-12-10 | — | — | EP | disclosed |
| US-20030022831-A1 | Compositions and methods for enhancing drug delivery across and into ocular tissues | CELLGATE, INC., A DELAWARE CORPORATION | 2003-01-30 | — | — | US | disclosed |
| WO-2002069930-A1 | COMPOSITIONS AND METHODS FOR ENHANCING DRUG DELIVERY ACROSS AND INTO EPITHELIAL TISSUES | CELLGATE, INC. (US) | 2002-09-12 | — | — | WO | disclosed |
| WO-2002067917-A1 | COMPOSITIONS AND METHODS FOR ENHANCING DRUG DELIVERY ACROSS AND INTO OCULAR TISSUES | CELLGATE, INC. (US) | 2002-09-06 | — | — | WO | disclosed |