Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17724326 | 0.82 | KDM4E (0.41) | MAPTKDM4EHSD17B10TSHRALOX15 | |
| SCHEMBL22990321 | 0.79 | KDM4E (0.44) | MAPTKDM4EHSD17B10TSHRALOX15 | |
| SCHEMBL11563753 | 0.79 | KDM4E (0.39) | MAPTKDM4EHSD17B10TSHRALOX15 | |
| SCHEMBL11563754 | 0.79 | KDM4E (0.39) | MAPTKDM4EHSD17B10TSHRALOX15 | |
| SCHEMBL7228350 | 0.79 | KDM4E (0.50) | MAPTKDM4EHSD17B10TSHRALOX15 | |
| SCHEMBL70060 | 0.78 | KDM4E (0.54) | MAPTKDM4EHSD17B10TSHRALOX15 | |
| SCHEMBL11562171 | 0.78 | KDM4E (0.41) | MAPTKDM4EHSD17B10TSHRALOX15 | |
| SCHEMBL11562173 | 0.78 | KDM4E (0.41) | MAPTKDM4EHSD17B10TSHRALOX15 | |
| SCHEMBL11561471 | 0.77 | KDM4E (0.40) | MAPTKDM4EHSD17B10TSHRALOX15 | |
| SCHEMBL11564268 | 0.77 | KDM4E (0.40) | MAPTKDM4EHSD17B10TSHRALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2629771-B1 | USE OF PI3K INHIBITORS FOR THE TREATMENT OF OBESITY, STEATOSIS AND AGEING | FUNDACION CENTRO NAC DE INVESTIGACIONES ONCOLOGICAS CARLOS III (ES) | 2018-08-08 | — | — | EP | disclosed |
| WO-2012052745-A1 | COMBINATIONS OF PI3K INHIBITORS WITH A SECOND ANTI -TUMOR AGENT | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-04-26 | — | — | WO | disclosed |