Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | CDK2 | P24941 | 1/20 | 0.59 |
| ▸ | CNR2 | P34972 | 3/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 4/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | CTSV | O60911 | 3/20 | 0.46 |
| ▸ | CTSL | P07711 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GABRP | O00591 | 1/20 | 0.44 |
| ▸ | GABRD | O14764 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4050016 | 0.86 | HPGD (0.50) | MAPTHPGDCDK2CNR2CNR1 | |
| SCHEMBL14979171 | 0.83 | MEN1 (0.55) | MAPTHPGDCDK2CNR2CNR1 | |
| SCHEMBL2468319 | 0.82 | MAPT (0.54) | MAPTHPGDCDK2CNR2CNR1 | |
| SCHEMBL3346790 | 0.80 | MAPT (0.57) | MAPTHPGDCDK2CNR2CNR1 | |
| Iodide SCHEMBL5922463 | 0.80 | MAPT (0.57) | MAPTHPGDCDK2CNR2CNR1 | |
| SCHEMBL11412120 | 0.80 | CDK2 (0.57) | MAPTHPGDCDK2CNR2CNR1 | |
| SCHEMBL761212 | 0.79 | CDK2 (0.69) | MAPTHPGDCDK2CNR2CNR1 | |
| SCHEMBL25223963 | 0.78 | MAPT (0.55) | MAPTHPGDCDK2CNR2CNR1 | |
| SCHEMBL3343737 | 0.78 | MAPT (0.55) | MAPTHPGDCDK2CNR2CNR1 | |
| SCHEMBL27751025 | 0.78 | MAPT (0.55) | MAPTHPGDCDK2CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569937-A4 | C-6 MODIFIED INDAZOLYLPYRROLOTRIAZINES | BRISTOL MYERS SQUIBB CO (US) | 2007-08-08 | — | — | EP | disclosed |
| EP-1569937-A2 | C-6 MODIFIED INDAZOLYLPYRROLOTRIAZINES | Bristol-Myers Squibb Company (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004054514-A2 | C-6 MODIFIED INDAZOLYLPYRROLOTRIAZINES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-07-01 | — | — | WO | disclosed |