Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 7/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 7/20 | 0.41 |
| ▸ | PTGIR | P43119 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.32 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5797204 | 0.89 | AKR1C3 (0.38) | AKR1C3AKR1C2PTGIRLMNACYP1A2 | |
| SCHEMBL5800601 | 0.87 | AKR1C3 (0.44) | AKR1C3AKR1C2PTGIRLMNACYP1A2 | |
| SCHEMBL5800085 | 0.84 | AKR1C3 (0.40) | AKR1C3AKR1C2LMNACYP1A2CYP2D6 | |
| SCHEMBL6424956 | 0.83 | AKR1C3 (0.38) | AKR1C3AKR1C2LMNACYP2D6TSHR | |
| SCHEMBL6423624 | 0.83 | AKR1C3 (0.38) | AKR1C3AKR1C2LMNACYP2D6TSHR | |
| SCHEMBL5560372 | 0.83 | AKR1C3 (0.38) | AKR1C3AKR1C2LMNACYP2D6TSHR | |
| SCHEMBL6425560 | 0.83 | AKR1C3 (0.38) | AKR1C3AKR1C2LMNACYP2D6TSHR | |
| SCHEMBL5561345 | 0.83 | AKR1C3 (0.38) | AKR1C3AKR1C2LMNACYP2D6TSHR | |
| SCHEMBL5558739 | 0.82 | AKR1C3 (0.57) | AKR1C3AKR1C2PTGIRLMNACYP1A2 | |
| SCHEMBL5798162 | 0.81 | AKR1C3 (0.47) | AKR1C3AKR1C2LMNACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643961-A4 | COX-2 AND FAAH INHIBITORS | MICROBIA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| EP-1643961-A2 | COX-2 AND FAAH INHIBITORS | Microbia, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005002525-A2 | COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2005-01-13 | — | — | WO | disclosed |