Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 11/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 11/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5634604 | 0.84 | MAPK13 (0.59) | MAPK13MAPK12MAPK11MAPK14KDM4E | |
| SCHEMBL5560185 | 0.84 | MAPK13 (0.54) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5559313 | 0.83 | MAPK13 (0.53) | MAPK13MAPK12MAPK11MAPK14NPC1 | |
| SCHEMBL5634600 | 0.77 | NPC1 (0.70) | MAPK13MAPK12MAPK11MAPK14NPC1 | |
| SCHEMBL5634175 | 0.76 | MAPK14 (0.60) | MAPK13MAPK12MAPK11MAPK14KDM4E | |
| SCHEMBL5634397 | 0.75 | MAPK13 (0.74) | MAPK13MAPK12MAPK11MAPK14KDM4E | |
| SCHEMBL5634110 | 0.75 | MAPK13 (0.67) | MAPK13MAPK12MAPK11MAPK14KDM4E | |
| SCHEMBL5389328 | 0.75 | MAPK14 (0.60) | MAPK13MAPK12MAPK11MAPK14KDM4E | |
| SCHEMBL5559309 | 0.75 | MAPK14 (0.59) | MAPK13MAPK12MAPK11MAPK14KDM4E | |
| SCHEMBL5395408 | 0.75 | MAPK13 (0.76) | MAPK13MAPK12MAPK11MAPK14NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658288-B1 | 2-AMINO-5-BENZOYLTHIAZOLE NPY ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2007-12-05 | — | — | EP | claimed |