Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 2/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | BLK | P51451 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5560972 | 0.93 | MAPK13 (0.47) | MAPK13MAPK12MAPK11MAPK14NPC1 | |
| SCHEMBL5555370 | 0.93 | MAPK13 (0.49) | MAPK13MAPK12MAPK11MAPK14NPC1 | |
| SCHEMBL5398164 | 0.88 | NPC1 (0.50) | MAPK13MAPK12MAPK11MAPK14NPC1 | |
| SCHEMBL5554586 | 0.87 | MAPK13 (0.50) | MAPK13MAPK12MAPK11MAPK14NPC1 | |
| SCHEMBL5559745 | 0.86 | MAPK13 (0.49) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5554708 | 0.86 | MAPK13 (0.49) | MAPK13MAPK12MAPK11MAPK14NPC1 | |
| SCHEMBL5554668 | 0.85 | MAPK13 (0.48) | MAPK13MAPK12MAPK11MAPK14RAB9A | |
| SCHEMBL5559636 | 0.84 | MAPK13 (0.50) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL5555031 | 0.84 | MEN1 (0.42) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL5554647 | 0.83 | MAPK13 (0.42) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658288-B1 | 2-AMINO-5-BENZOYLTHIAZOLE NPY ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2007-12-05 | — | — | EP | disclosed |