Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.75 |
| ▸ | PDE4A | P27815 | 17/20 | 0.75 |
| ▸ | PDE4C | Q08493 | 17/20 | 0.75 |
| ▸ | PDE4D | Q08499 | 17/20 | 0.75 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5554956 | 1.00 | PDE4B (0.75) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL5560160 | 0.90 | PDE4D (0.75) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL6029275 | 0.90 | PDE4B (0.78) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL5554911 | 0.89 | PDE4B (0.74) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL5554908 | 0.89 | PDE4B (0.74) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL5554917 | 0.89 | PDE4B (0.74) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL6031161 | 0.89 | PDE4B (0.73) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL6027861 | 0.88 | PDE4A (0.75) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL6029447 | 0.88 | PDE4B (0.72) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL6030602 | 0.88 | PDE4A (0.75) | PDE4BPDE4APDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228046-B1 | PHTHALAZINONE DERIVATIVES AS PDE 4 INHIBITORS | NYCOMED GMBH (DE) | 2007-09-26 | — | — | EP | claimed |
| EP-1228046-B1 | PHTHALAZINONE DERIVATIVES AS PDE 4 INHIBITORS | NYCOMED GMBH (DE) | 2007-09-26 | — | — | EP | disclosed |
| US-6756371-B1 | MORPHOLINO OR THIOMORPHOLINO DERIVATIVES; RESPIRATORY SYSTEM DISORDERS | ALTANA PHARMA AG (DE) | 2004-06-29 | — | — | US | disclosed |