Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 3/20 | 0.61 |
| ▸ | JAK2 | O60674 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | JAK3 | P52333 | 1/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 14/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.49 |
| ▸ | ERO1A | Q96HE7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7055208 | 0.90 | IKBKB (0.75) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL5555739 | 0.88 | IKBKB (0.57) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL3086954 | 0.86 | IKBKB (0.82) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL3077226 | 0.83 | CHEK1 (0.65) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL5550845 | 0.83 | JAK2 (0.67) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL3074554 | 0.82 | IKBKB (0.62) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL1563740 | 0.81 | IKBKB (0.83) | IKBKBJAK2JAK3CHEK1MAP4K4 | |
| SCHEMBL5551130 | 0.80 | CHEK1 (0.60) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL3069626 | 0.80 | IKBKB (0.67) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL5898635 | 0.80 | IKBKB (0.60) | IKBKBJAK2MEN1EIF2AK2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010556-A1 | Thiophene derivatives as chk 1 inhibitors | ASTRAZENECA AB (SE) | 2007-01-11 | — | — | US | disclosed |
| EP-1732920-A2 | THIOPHENE DERIVATIVES AS CHK 1 INHIBITORS | AstraZeneca AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005066163-A2 | THIOPHENE DERIVATIVES AS CHK 1 INIHIBITORS | ASTRAZENECA AB (SE) | 2005-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010556-A1 | Thiophene derivatives as chk 1 inhibitors | CHEK1, CHKA, CHEK2 | IKBKB 581/4885JAK2 1330/4885MEN1 3068/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.