Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMG1 | Q96Q15 | 2/20 | 0.65 |
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.63 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.61 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.56 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.53 |
| ▸ | MST1 | P26927 | 1/20 | 0.53 |
| ▸ | STK4 | Q13043 | 1/20 | 0.53 |
| ▸ | STK3 | Q13188 | 1/20 | 0.53 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.53 |
| ▸ | PRKDC | P78527 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5558231 | 0.88 | SMG1 (0.51) | SMG1LRRK2PDE4DGRM5CLK4 | |
| SCHEMBL1715860 | 0.84 | LRRK2 (0.62) | SMG1LRRK2PDE4DABL1TBK1 | |
| SCHEMBL20004324 | 0.80 | LRRK2 (0.53) | SMG1LRRK2STK4STK3PRKDC | |
| SCHEMBL248414 | 0.79 | LRRK2 (0.56) | SMG1LRRK2PDE4DTBK1MST1 | |
| SCHEMBL1443007 | 0.78 | PDE4D (0.55) | SMG1LRRK2PDE4DKCNH2TNIK | |
| SCHEMBL30481277 | 0.77 | PDE4D (0.66) | LRRK2PDE4DKDM4E | |
| SCHEMBL16025486 | 0.77 | LRRK2 (0.86) | LRRK2ABL1 | |
| SCHEMBL31438228 | 0.76 | SMG1 (0.56) | SMG1LRRK2PIK3CA | |
| SCHEMBL31554954 | 0.75 | PIK3CA (0.73) | SMG1LRRK2PRKDCPIK3CA | |
| SCHEMBL16022908 | 0.75 | LRRK2 (1.00) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474416-B1 | DIHYDROBENZODIAZEPIN-2-ONE-DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | HOFFMANN LA ROCHE (CH) | 2007-09-26 | — | — | EP | disclosed |
| US-6949542-B2 | Dihydro-benzo[b][1,4]diazepin-2-one derivatives | HOFFMAN-LA ROCHE INC. (US) | 2005-09-27 | — | — | US | disclosed |
| EP-1474416-A1 | DIHYDROBENZODIAZEPIN-2-ONE-DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-10 | — | — | EP | disclosed |
| US-20030166639-A1 | Dihydro-benzo[b][1,4]diazepin-2-one derivatives | F. HOFFMAN-LA ROCHE AG (CH) | 2003-09-04 | — | — | US | disclosed |
| WO-2003066623-A1 | DIHYDROBENZODIAZEPIN-2-ONE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166639-A1 | Dihydro-benzo[b][1,4]diazepin-2-one derivatives | CYP1B1, GRIN2B, CYP4B1 | SMG1 3939/4885LRRK2 2338/4885PDE4D 706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.